Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LYPLA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYPLA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYPLA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:23,530,568–23,531,711 | 259.9 kb | Distal (>10kb) Multiome | 775 | |
| chr1:23,539,704–23,540,280 | 251.2 kb | Distal (>10kb) Multiome | 668 | |
| chr1:23,554,367–23,556,627 | 236.2 kb | Distal (>10kb) Multiome | 961 | |
| chr1:23,558,135–23,559,925 | 231.6 kb | Distal (>10kb) Multiome | 932 | |
| chr1:23,598,114–23,599,073 | 192.6 kb | Distal (>10kb) Multiome | 329 | |
| chr1:23,691,587–23,692,258 | 99.4 kb | Distal (>10kb) Multiome | 876 | |
| chr1:23,742,958–23,744,137 | 47.8 kb | Distal (>10kb) Multiome | 802 | |
| chr1:23,777,908–23,778,814 | 12.8 kb | Distal (>10kb) Multiome | 849 | |
| chr1:23,790,777–23,791,448 | 52 bp | At TSS Multiome | 637 | |
| chr1:23,791,670–23,792,006 | 484 bp | At TSS | 256 | |
| chr1:23,799,493–23,801,538 | 9.7 kb | Proximal (<10kb) Multiome | 922 | |
| chr1:23,825,075–23,825,633 | 34.3 kb | Distal (>10kb) Multiome | 867 | |
| chr1:23,867,741–23,868,918 | 77.2 kb | Distal (>10kb) Multiome | 766 | |
| chr1:23,958,982–23,960,271 | 168.6 kb | Distal (>10kb) Multiome | 1051 | |
| chr1:23,979,815–23,981,031 | 189.2 kb | Distal (>10kb) Multiome | 1078 | |
| chr1:23,998,624–23,999,076 | 207.7 kb | Distal (>10kb) Multiome | 19 |
Genomic view of the LYPLA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.