Enables acetylcholine receptor regulator activity. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LYPD6B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYPD6B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYPD6B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:148,813,520–148,814,415 | 224.2 kb | Distal (>10kb) Multiome | 315 | |
| chr2:148,874,671–148,877,521 | 162.9 kb | Distal (>10kb) Multiome | 652 | |
| chr2:148,998,911–149,000,002 | 38.6 kb | Distal (>10kb) Multiome | 79 | |
| chr2:149,033,707–149,034,023 | 4.1 kb | Proximal (<10kb) | 43 | |
| chr2:149,037,769–149,039,431 | 638 bp | At TSS Multiome | 414 | |
| chr2:149,040,547–149,040,788 | 2.4 kb | Proximal (<10kb) | 125 | |
| chr2:149,124,742–149,125,882 | 87.2 kb | Distal (>10kb) Multiome | 256 | |
| chr2:149,329,167–149,331,592 | 292.4 kb | Distal (>10kb) Multiome HiCAR | 688 | |
| chr2:149,587,059–149,588,359 | 549.6 kb | Distal (>10kb) Multiome HiCAR | 991 |
Genomic view of the LYPD6B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.