Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Located in cytosol and nucleoplasm. Implicated in inflammatory poikiloderma with hair abnormalities and acral keratoses. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LTV1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LTV1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LTV1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:143,536,309–143,537,965 | 306.0 kb | Distal (>10kb) Multiome HiCAR | 577 | |
| chr6:143,598,354–143,599,128 | 244.5 kb | Distal (>10kb) Multiome HiCAR | 303 | |
| chr6:143,677,404–143,678,655 | 165.3 kb | Distal (>10kb) Multiome HiCAR | 774 | |
| chr6:143,746,106–143,747,905 | 95.8 kb | Distal (>10kb) Multiome | 594 | |
| chr6:143,842,515–143,843,902 | 111 bp | At TSS Multiome | 1125 | |
| chr6:143,941,930–143,942,677 | 99.0 kb | Distal (>10kb) Multiome | 362 | |
| chr6:143,958,803–143,959,611 | 115.8 kb | Distal (>10kb) Multiome | 236 | |
| chr6:143,964,156–143,965,374 | 121.5 kb | Distal (>10kb) Multiome | 218 | |
| chr6:143,972,911–143,973,871 | 130.0 kb | Distal (>10kb) Multiome | 319 | |
| chr6:144,007,743–144,008,869 | 165.0 kb | Distal (>10kb) Multiome | 500 | |
| chr6:144,063,633–144,064,850 | 220.8 kb | Distal (>10kb) Multiome | 823 | |
| chr6:144,094,958–144,096,613 | 252.4 kb | Distal (>10kb) Multiome | 1009 |
Genomic view of the LTV1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.