LTBP4
latent transforming growth factor beta binding protein 4 | FLJ46318, FLJ90018, LTBP-4, LTBP-4L

The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Member of: DE-9 Developmental clusters: GC6
Biological processes 28 terms
calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)cell surface receptor protein serine/threonine kinase signaling pathway (GO:0007178)elastic fiber (GO:0071953)elastic fiber assembly (GO:0048251)extracellular matrix (GO:0031012)extracellular matrix (GO:0031012)extracellular matrix (GO:0031012)extracellular matrix (GO:0031012)extracellular matrix (GO:0031012)extracellular matrix structural constituent (GO:0005201)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)glycosaminoglycan binding (GO:0005539)integrin binding (GO:0005178)microfibril (GO:0001527)protein binding (GO:0005515)protein folding (GO:0006457)regulation of cell growth (GO:0001558)regulation of transforming growth factor beta receptor signaling pathway (GO:0017015)transforming growth factor beta binding (GO:0050431)transforming growth factor beta binding (GO:0050431)transforming growth factor beta binding (GO:0050431)transforming growth factor beta binding (GO:0050431)transforming growth factor beta complex (GO:0099126)transforming growth factor beta receptor activity (GO:0005024)
Expression (TPM)
LTBP4 — as a Regulated Gene

TFs regulating LTBP4 0 TFs

Transcription factors with Perturb-seq knockdown data for LTBP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LTBP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to LTBP4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LTBP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:40,347,917–40,348,964 264.9 kb Distal (>10kb) Multiome 843
chr19:40,365,649–40,366,111 247.6 kb Distal (>10kb) Multiome 244
chr19:40,398,541–40,399,285 214.5 kb Distal (>10kb) Multiome 234
chr19:40,403,323–40,404,681 209.8 kb Distal (>10kb) Multiome 638
chr19:40,420,702–40,421,699 192.3 kb Distal (>10kb) Multiome 966
chr19:40,424,783–40,426,631 187.4 kb Distal (>10kb) Multiome 954
chr19:40,433,505–40,434,546 179.4 kb Distal (>10kb) Multiome 791
chr19:40,442,698–40,445,144 170.2 kb Distal (>10kb) Multiome 994
chr19:40,465,326–40,466,635 147.5 kb Distal (>10kb) Multiome 815
chr19:40,487,850–40,488,306 125.3 kb Distal (>10kb) Multiome 193
chr19:40,519,457–40,519,993 93.7 kb Distal (>10kb) Multiome 222
chr19:40,528,978–40,529,879 84.1 kb Distal (>10kb) Multiome 601
chr19:40,529,987–40,530,863 82.8 kb Distal (>10kb) Multiome 384
chr19:40,549,036–40,549,555 64.0 kb Distal (>10kb) Multiome 372
chr19:40,570,181–40,571,253 42.7 kb Distal (>10kb) Multiome 598
chr19:40,576,133–40,577,495 36.6 kb Distal (>10kb) Multiome 616
chr19:40,596,828–40,597,429 16.4 kb Distal (>10kb) Multiome 354
chr19:40,598,094–40,598,871 14.9 kb Distal (>10kb) Multiome 606
chr19:40,601,096–40,601,602 3.9 kb Proximal (<10kb) 276
chr19:40,602,700–40,602,861 5.5 kb Proximal (<10kb) 316
chr19:40,603,345–40,604,624 9.3 kb Proximal (<10kb) Multiome 889
chr19:40,604,983–40,606,597 7.7 kb Proximal (<10kb) Multiome 708
chr19:40,609,543–40,610,691 3.3 kb Proximal (<10kb) Multiome 519
chr19:40,612,884–40,615,179 249 bp At TSS Multiome 595
chr19:40,623,557–40,624,516 10.6 kb Distal (>10kb) Multiome 454
chr19:40,634,333–40,634,959 21.2 kb Distal (>10kb) Multiome 629
chr19:40,662,838–40,663,654 49.6 kb Distal (>10kb) Multiome 856
chr19:40,689,888–40,691,759 77.4 kb Distal (>10kb) Multiome 691
chr19:40,714,822–40,715,454 101.7 kb Distal (>10kb) Multiome 531
chr19:40,716,605–40,717,875 103.6 kb Distal (>10kb) Multiome 772
chr19:40,750,206–40,751,874 137.4 kb Distal (>10kb) Multiome 989
chr19:40,777,237–40,779,173 164.9 kb Distal (>10kb) Multiome 901
chr19:40,798,002–40,799,843 185.6 kb Distal (>10kb) Multiome 936
chr19:40,806,580–40,807,205 193.6 kb Distal (>10kb) Multiome 496
chr19:40,810,733–40,811,261 197.6 kb Distal (>10kb) Multiome 115

Genome Browser

Genomic view of the LTBP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:40,337,917 – 40,821,261
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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