Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for LSM14A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LSM14A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LSM14A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:33,777,882–33,778,531 | 394.3 kb | Distal (>10kb) Multiome HiCAR | 668 | |
| chr19:33,795,218–33,798,802 | 376.8 kb | Distal (>10kb) Multiome HiCAR | 887 | |
| chr19:33,819,821–33,820,728 | 352.3 kb | Distal (>10kb) Multiome HiCAR | 512 | |
| chr19:33,905,451–33,907,250 | 266.2 kb | Distal (>10kb) Multiome | 371 | |
| chr19:33,958,246–33,958,760 | 214.0 kb | Distal (>10kb) Multiome | 13 | |
| chr19:34,134,218–34,135,012 | 37.9 kb | Distal (>10kb) Multiome | 833 | |
| chr19:34,171,846–34,173,343 | 104 bp | At TSS Multiome | 945 | |
| chr19:34,173,444–34,173,583 | 941 bp | At TSS | 487 | |
| chr19:34,254,036–34,255,321 | 82.1 kb | Distal (>10kb) Multiome | 742 | |
| chr19:34,358,965–34,360,056 | 186.9 kb | Distal (>10kb) Multiome | 865 | |
| chr19:34,364,839–34,365,605 | 192.6 kb | Distal (>10kb) Multiome | 554 | |
| chr19:34,404,022–34,405,020 | 231.9 kb | Distal (>10kb) Multiome | 883 | |
| chr19:34,428,165–34,428,863 | 255.9 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the LSM14A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.