Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRFIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRFIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRFIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:237,474,991–237,476,037 | 152.1 kb | Distal (>10kb) Multiome | 709 | |
| chr2:237,486,474–237,487,637 | 140.5 kb | Distal (>10kb) Multiome | 294 | |
| chr2:237,512,627–237,513,282 | 114.6 kb | Distal (>10kb) Multiome | 464 | |
| chr2:237,571,806–237,573,114 | 55.4 kb | Distal (>10kb) Multiome | 536 | |
| chr2:237,594,513–237,595,741 | 32.5 kb | Distal (>10kb) Multiome | 605 | |
| chr2:237,601,754–237,602,212 | 25.6 kb | Distal (>10kb) Multiome | 364 | |
| chr2:237,603,751–237,604,242 | 23.6 kb | Distal (>10kb) Multiome | 230 | |
| chr2:237,614,157–237,614,906 | 13.1 kb | Distal (>10kb) Multiome | 629 | |
| chr2:237,626,957–237,628,263 | 13 bp | At TSS Multiome | 380 | |
| chr2:237,662,692–237,663,153 | 35.3 kb | Distal (>10kb) Multiome | 271 | |
| chr2:237,691,002–237,693,099 | 64.4 kb | Distal (>10kb) Multiome | 713 |
Genomic view of the LRRFIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.