This gene encodes a centrosomal protein that maintains the structural integrity of the centrosome and plays a key role in mitotic spindle formation. The encoded protein contains an N-terminal leucine-rich repeat domain and a C-terminal coiled-coil domain. It associates with the centrosome throughout the cell cycle and accumulates on the mitotic centrosome. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for LRRCC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRCC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRCC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:84,900,401–84,902,474 | 206.3 kb | Distal (>10kb) Multiome | 293 | |
| chr8:85,106,583–85,108,304 | 33 bp | At TSS Multiome | 759 | |
| chr8:85,108,361–85,108,870 | 1.1 kb | Proximal (<10kb) | 76 | |
| chr8:85,176,569–85,178,114 | 70.0 kb | Distal (>10kb) Multiome | 922 | |
| chr8:85,219,878–85,221,874 | 113.3 kb | Distal (>10kb) Multiome | 895 | |
| chr8:85,244,896–85,246,268 | 138.5 kb | Distal (>10kb) Multiome | 796 |
Genomic view of the LRRCC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.