Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC75A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC75A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC75A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:16,214,816–16,216,252 | 276.6 kb | Distal (>10kb) Multiome | 888 | |
| chr17:16,217,055–16,217,691 | 274.9 kb | Distal (>10kb) Multiome | 911 | |
| chr17:16,352,703–16,353,919 | 138.7 kb | Distal (>10kb) Multiome | 714 | |
| chr17:16,380,399–16,381,729 | 111.3 kb | Distal (>10kb) Multiome | 1044 | |
| chr17:16,386,465–16,387,421 | 105.3 kb | Distal (>10kb) Multiome | 448 | |
| chr17:16,406,971–16,407,704 | 84.8 kb | Distal (>10kb) Multiome | 340 | |
| chr17:16,438,359–16,439,725 | 53.3 kb | Distal (>10kb) Multiome | 1006 | |
| chr17:16,442,894–16,444,373 | 48.3 kb | Distal (>10kb) Multiome | 388 | |
| chr17:16,488,572–16,488,784 | 3.4 kb | Proximal (<10kb) | 91 | |
| chr17:16,491,363–16,492,722 | 15 bp | At TSS Multiome | 312 | |
| chr17:16,535,515–16,536,276 | 43.6 kb | Distal (>10kb) Multiome | 814 | |
| chr17:16,536,612–16,537,145 | 44.9 kb | Distal (>10kb) Multiome | 360 | |
| chr17:16,568,720–16,569,381 | 77.0 kb | Distal (>10kb) Multiome | 379 | |
| chr17:16,588,994–16,589,833 | 97.2 kb | Distal (>10kb) Multiome | 573 | |
| chr17:16,653,205–16,654,064 | 161.5 kb | Distal (>10kb) Multiome | 830 |
Genomic view of the LRRC75A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.