Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC49. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC49 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC49, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:70,584,932–70,585,627 | 268.0 kb | Distal (>10kb) Multiome | 463 | |
| chr15:70,762,521–70,764,044 | 89.8 kb | Distal (>10kb) Multiome | 805 | |
| chr15:70,853,264–70,854,729 | 784 bp | At TSS Multiome | 472 | |
| chr15:70,891,888–70,893,094 | 39.2 kb | Distal (>10kb) Multiome | 794 | |
| chr15:71,085,589–71,086,284 | 232.6 kb | Distal (>10kb) Multiome | 153 | |
| chr15:71,114,765–71,116,364 | 262.1 kb | Distal (>10kb) Multiome | 625 |
Genomic view of the LRRC49 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.