Predicted to be involved in intracellular signal transduction. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC40. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC40 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC40, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:68,231,101–68,233,483 | 1973.0 kb | Distal (>10kb) Multiome HiCAR | 557 | |
| chr1:68,496,039–68,497,758 | 1708.4 kb | Distal (>10kb) Multiome HiCAR | 831 | |
| chr1:70,204,918–70,206,272 | 96 bp | At TSS Multiome | 947 | |
| chr1:70,220,975–70,221,995 | 15.9 kb | Distal (>10kb) Multiome | 912 | |
| chr1:70,353,684–70,355,124 | 149.1 kb | Distal (>10kb) Multiome | 1038 | |
| chr1:70,410,268–70,411,834 | 205.5 kb | Distal (>10kb) Multiome | 925 |
Genomic view of the LRRC40 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.