Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC37A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC37A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC37A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:64,661,214–64,662,931 | 257.2 kb | Distal (>10kb) Multiome | 700 | |
| chr17:64,773,965–64,774,847 | 145.1 kb | Distal (>10kb) Multiome | 481 | |
| chr17:64,776,631–64,777,384 | 142.4 kb | Distal (>10kb) Multiome | 616 | |
| chr17:64,778,215–64,779,097 | 140.8 kb | Distal (>10kb) Multiome | 185 | |
| chr17:64,779,868–64,781,331 | 139.0 kb | Distal (>10kb) Multiome | 287 | |
| chr17:64,836,863–64,837,361 | 82.3 kb | Distal (>10kb) Multiome | 286 | |
| chr17:64,918,788–64,920,342 | 62 bp | At TSS Multiome | 704 | |
| chr17:64,923,011–64,923,153 | 3.5 kb | Proximal (<10kb) | 155 | |
| chr17:64,975,096–64,976,234 | 56.1 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:65,055,840–65,057,373 | 137.3 kb | Distal (>10kb) Multiome | 946 | |
| chr17:65,057,526–65,058,894 | 138.9 kb | Distal (>10kb) Multiome | 300 | |
| chr17:65,100,219–65,101,279 | 181.3 kb | Distal (>10kb) Multiome | 634 | |
| chr17:65,123,077–65,123,614 | 203.9 kb | Distal (>10kb) Multiome | 724 | |
| chr17:65,136,968–65,137,867 | 217.8 kb | Distal (>10kb) Multiome | 573 |
Genomic view of the LRRC37A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.