Transcription factors with Perturb-seq knockdown data for LRIG2-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRIG2-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRIG2-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,714,149–112,716,774 | 356.5 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr1:112,790,881–112,791,569 | 281.8 kb | Distal (>10kb) Multiome | 158 | |
| chr1:112,794,180–112,795,498 | 278.0 kb | Distal (>10kb) Multiome | 251 | |
| chr1:112,809,091–112,810,187 | 263.5 kb | Distal (>10kb) Multiome HiCAR | 445 | |
| chr1:112,817,716–112,818,473 | 255.0 kb | Distal (>10kb) Multiome | 249 | |
| chr1:112,819,120–112,820,730 | 253.7 kb | Distal (>10kb) Multiome | 456 | |
| chr1:112,825,474–112,826,954 | 247.2 kb | Distal (>10kb) Multiome HiCAR | 182 | |
| chr1:112,841,024–112,841,798 | 231.7 kb | Distal (>10kb) Multiome | 215 | |
| chr1:112,849,324–112,850,157 | 223.3 kb | Distal (>10kb) Multiome HiCAR | 352 | |
| chr1:112,955,281–112,957,849 | 116.8 kb | Distal (>10kb) Multiome | 1108 | |
| chr1:113,040,180–113,041,009 | 32.7 kb | Distal (>10kb) Multiome | 248 | |
| chr1:113,041,702–113,043,423 | 30.3 kb | Distal (>10kb) Multiome | 544 | |
| chr1:113,043,627–113,044,178 | 29.1 kb | Distal (>10kb) Multiome | 105 | |
| chr1:113,072,181–113,073,766 | 41 bp | At TSS Multiome | 975 | |
| chr1:113,140,616–113,141,422 | 67.9 kb | Distal (>10kb) Multiome | 413 | |
| chr1:113,217,521–113,218,452 | 144.9 kb | Distal (>10kb) Multiome | 479 | |
| chr1:113,223,494–113,224,107 | 150.7 kb | Distal (>10kb) Multiome | 75 | |
| chr1:113,234,064–113,234,645 | 161.3 kb | Distal (>10kb) Multiome | 67 | |
| chr1:113,252,166–113,252,950 | 179.3 kb | Distal (>10kb) Multiome | 98 |
Genomic view of the LRIG2-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.