Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRATD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRATD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRATD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:126,368,945–126,369,496 | 189.3 kb | Distal (>10kb) Multiome | 132 | |
| chr8:126,422,800–126,424,054 | 135.2 kb | Distal (>10kb) Multiome HiCAR | 251 | |
| chr8:126,449,372–126,449,956 | 108.8 kb | Distal (>10kb) Multiome | 184 | |
| chr8:126,510,314–126,510,851 | 48.0 kb | Distal (>10kb) Multiome | 218 | |
| chr8:126,544,813–126,545,611 | 13.2 kb | Distal (>10kb) Multiome | 178 | |
| chr8:126,555,279–126,559,084 | 2.8 kb | Proximal (<10kb) Multiome | 996 | |
| chr8:126,565,779–126,566,252 | 8.0 kb | Proximal (<10kb) | 58 | |
| chr8:126,566,985–126,567,193 | 9.3 kb | Proximal (<10kb) | 69 | |
| chr8:126,824,441–126,825,287 | 266.3 kb | Distal (>10kb) Multiome | 383 |
Genomic view of the LRATD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.