This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for LOXL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LOXL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LOXL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:73,632,366–73,634,024 | 293.0 kb | Distal (>10kb) Multiome | 802 | |
| chr15:73,636,471–73,636,966 | 289.9 kb | Distal (>10kb) Multiome | 427 | |
| chr15:73,683,662–73,685,097 | 242.2 kb | Distal (>10kb) Multiome | 641 | |
| chr15:73,733,109–73,733,828 | 192.9 kb | Distal (>10kb) Multiome | 33 | |
| chr15:73,752,465–73,753,181 | 173.6 kb | Distal (>10kb) Multiome | 192 | |
| chr15:73,926,301–73,928,142 | 1.3 kb | Proximal (<10kb) Multiome | 557 | |
| chr15:73,964,793–73,965,395 | 38.5 kb | Distal (>10kb) Multiome | 395 | |
| chr15:73,972,958–73,973,626 | 46.7 kb | Distal (>10kb) Multiome | 375 | |
| chr15:73,991,853–73,992,729 | 65.9 kb | Distal (>10kb) Multiome | 723 | |
| chr15:73,994,310–73,995,392 | 68.2 kb | Distal (>10kb) Multiome | 539 | |
| chr15:74,124,047–74,124,500 | 197.9 kb | Distal (>10kb) Multiome | 16 | |
| chr15:74,127,396–74,128,614 | 201.3 kb | Distal (>10kb) Multiome | 498 | |
| chr15:74,129,520–74,130,600 | 203.6 kb | Distal (>10kb) Multiome | 188 | |
| chr15:74,134,110–74,134,917 | 208.1 kb | Distal (>10kb) Multiome | 220 | |
| chr15:74,135,992–74,136,743 | 209.9 kb | Distal (>10kb) Multiome | 439 | |
| chr15:74,202,453–74,203,387 | 276.5 kb | Distal (>10kb) Multiome | 381 | |
| chr15:74,208,748–74,209,470 | 282.7 kb | Distal (>10kb) Multiome | 233 |
Genomic view of the LOXL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.