Predicted to enable zinc ion binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LONRF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LONRF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LONRF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:12,658,949–12,659,733 | 96.1 kb | Distal (>10kb) Multiome | 99 | |
| chr8:12,665,053–12,665,814 | 89.9 kb | Distal (>10kb) Multiome | 140 | |
| chr8:12,753,428–12,756,452 | 1.5 kb | Proximal (<10kb) Multiome | 959 | |
| chr8:12,951,067–12,952,574 | 196.3 kb | Distal (>10kb) Multiome | 496 | |
| chr8:12,972,190–12,973,116 | 217.1 kb | Distal (>10kb) Multiome | 182 | |
| chr8:13,041,246–13,042,612 | 286.1 kb | Distal (>10kb) Multiome | 464 |
Genomic view of the LONRF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.