Enables RNA binding activity. Predicted to be involved in dendrite extension and positive regulation of dendritic spine development. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LLPH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LLPH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LLPH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:65,845,814–65,846,311 | 284.8 kb | Distal (>10kb) Multiome | 145 | |
| chr12:65,897,482–65,897,992 | 233.0 kb | Distal (>10kb) Multiome | 129 | |
| chr12:65,925,832–65,927,041 | 204.4 kb | Distal (>10kb) Multiome | 384 | |
| chr12:66,061,688–66,062,514 | 68.6 kb | Distal (>10kb) Multiome | 137 | |
| chr12:66,130,651–66,131,145 | at TSS | At TSS | 729 | |
| chr12:66,169,293–66,170,152 | 39.0 kb | Distal (>10kb) Multiome | 1068 | |
| chr12:66,188,883–66,189,740 | 58.5 kb | Distal (>10kb) Multiome | 387 | |
| chr12:66,235,081–66,235,617 | 104.6 kb | Distal (>10kb) Multiome | 221 | |
| chr12:66,301,849–66,302,942 | 171.7 kb | Distal (>10kb) Multiome | 756 |
Genomic view of the LLPH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.