Transcription factors with Perturb-seq knockdown data for LIX1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIX1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIX1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:96,807,053–96,808,809 | 280.8 kb | Distal (>10kb) Multiome | 1054 | |
| chr5:96,934,346–96,937,145 | 154.1 kb | Distal (>10kb) Multiome | 1171 | |
| chr5:97,088,904–97,089,552 | at TSS | At TSS | 153 | |
| chr5:97,097,521–97,097,948 | 8.4 kb | Proximal (<10kb) | 50 | |
| chr5:97,142,252–97,143,299 | 53.7 kb | Distal (>10kb) Multiome | 308 | |
| chr5:97,182,741–97,184,087 | 94.5 kb | Distal (>10kb) Multiome | 963 | |
| chr5:97,192,555–97,193,805 | 104.1 kb | Distal (>10kb) Multiome | 303 |
Genomic view of the LIX1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.