Transcription factors with Perturb-seq knockdown data for LINC03051. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC03051 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC03051, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:117,626,264–117,627,164 | 370.8 kb | Distal (>10kb) Multiome HiCAR | 68 | |
| chr3:117,696,660–117,697,792 | 300.4 kb | Distal (>10kb) Multiome | 95 | |
| chr3:117,873,849–117,874,746 | 123.3 kb | Distal (>10kb) Multiome | 283 | |
| chr3:117,996,369–117,997,976 | 28 bp | At TSS Multiome | 422 |
Genomic view of the LINC03051 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.