Transcription factors with Perturb-seq knockdown data for LINC02700. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02700 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02700, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:94,351,024–94,351,644 | 286.8 kb | Distal (>10kb) Multiome | 45 | |
| chr11:94,400,876–94,402,024 | 236.6 kb | Distal (>10kb) Multiome | 221 | |
| chr11:94,493,226–94,494,559 | 144.2 kb | Distal (>10kb) Multiome | 772 | |
| chr11:94,512,016–94,512,839 | 125.6 kb | Distal (>10kb) Multiome | 343 | |
| chr11:94,543,659–94,545,776 | 93.8 kb | Distal (>10kb) Multiome | 824 | |
| chr11:94,643,177–94,643,647 | 5.4 kb | Proximal (<10kb) Multiome | 75 | |
| chr11:94,647,835–94,648,344 | 9.8 kb | Proximal (<10kb) | 80 | |
| chr11:94,734,354–94,735,444 | 96.6 kb | Distal (>10kb) Multiome HiCAR | 313 | |
| chr11:94,766,900–94,769,104 | 129.1 kb | Distal (>10kb) Multiome HiCAR | 701 | |
| chr11:94,866,030–94,867,452 | 228.6 kb | Distal (>10kb) Multiome HiCAR | 112 |
Genomic view of the LINC02700 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.