Transcription factors with Perturb-seq knockdown data for LINC02614. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02614 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02614, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:125,766,286–125,766,738 | 149.9 kb | Distal (>10kb) Multiome | 39 | |
| chr3:125,915,411–125,917,348 | 104 bp | At TSS Multiome | 435 | |
| chr3:125,921,840–125,922,033 | 5.5 kb | Proximal (<10kb) | 16 | |
| chr3:125,990,235–125,990,695 | 74.1 kb | Distal (>10kb) Multiome | 404 | |
| chr3:126,083,496–126,084,518 | 167.7 kb | Distal (>10kb) Multiome | 654 | |
| chr3:126,179,682–126,181,400 | 263.6 kb | Distal (>10kb) Multiome | 438 | |
| chr3:126,212,639–126,213,718 | 296.8 kb | Distal (>10kb) Multiome | 394 |
Genomic view of the LINC02614 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.