Transcription factors with Perturb-seq knockdown data for LINC02074. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02074 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02074, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:73,820,801–73,821,455 | 291.6 kb | Distal (>10kb) Multiome | 227 | |
| chr17:73,901,655–73,902,501 | 210.8 kb | Distal (>10kb) Multiome | 220 | |
| chr17:73,952,187–73,953,142 | 160.1 kb | Distal (>10kb) Multiome | 218 | |
| chr17:73,973,921–73,975,163 | 138.2 kb | Distal (>10kb) Multiome | 108 | |
| chr17:74,107,980–74,108,829 | 4.4 kb | Proximal (<10kb) Multiome | 70 | |
| chr17:74,116,073–74,116,358 | 3.2 kb | Proximal (<10kb) | 71 | |
| chr17:74,117,958–74,118,161 | 5.1 kb | Proximal (<10kb) | 16 | |
| chr17:74,118,558–74,118,928 | 5.7 kb | Proximal (<10kb) | 92 | |
| chr17:74,203,138–74,204,108 | 90.7 kb | Distal (>10kb) Multiome | 1032 | |
| chr17:74,210,772–74,213,995 | 100.6 kb | Distal (>10kb) Multiome | 756 | |
| chr17:74,296,413–74,296,895 | 183.8 kb | Distal (>10kb) Multiome | 369 | |
| chr17:74,325,836–74,326,504 | 213.3 kb | Distal (>10kb) Multiome | 237 | |
| chr17:74,351,773–74,352,296 | 239.1 kb | Distal (>10kb) Multiome | 202 | |
| chr17:74,379,476–74,379,948 | 266.8 kb | Distal (>10kb) Multiome | 522 |
Genomic view of the LINC02074 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.