Transcription factors with Perturb-seq knockdown data for LINC01866. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01866 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01866, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:16,961,166–16,961,889 | 8.1 kb | Proximal (<10kb) | 17 | |
| chr2:16,961,998–16,962,272 | 7.8 kb | Proximal (<10kb) | 19 | |
| chr2:16,962,542–16,962,940 | 7.1 kb | Proximal (<10kb) | 44 | |
| chr2:16,968,037–16,968,449 | 1.6 kb | Proximal (<10kb) | 34 |
Genomic view of the LINC01866 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.