Transcription factors with Perturb-seq knockdown data for LINC01473. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01473 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01473, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:186,058,717–186,058,992 | at TSS | At TSS | 23 | |
| chr2:186,485,510–186,487,147 | 427.5 kb | Distal (>10kb) Multiome | 1078 | |
| chr2:186,589,400–186,591,227 | 531.3 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:186,693,562–186,694,912 | 635.3 kb | Distal (>10kb) Multiome | 615 | |
| chr2:186,734,517–186,735,706 | 676.6 kb | Distal (>10kb) Multiome | 224 |
Genomic view of the LINC01473 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.