Transcription factors with Perturb-seq knockdown data for LINC01376. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01376 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01376, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:18,387,079–18,388,234 | 960.2 kb | Distal (>10kb) Multiome HiCAR | 366 | |
| chr2:18,559,599–18,561,088 | 787.4 kb | Distal (>10kb) Multiome HiCAR | 962 | |
| chr2:18,777,226–18,778,062 | 570.4 kb | Distal (>10kb) Multiome HiCAR | 358 | |
| chr2:18,836,102–18,837,761 | 511.3 kb | Distal (>10kb) Multiome HiCAR | 215 | |
| chr2:19,138,063–19,139,055 | 209.4 kb | Distal (>10kb) Multiome | 176 | |
| chr2:19,347,544–19,348,931 | 123 bp | At TSS Multiome | 939 | |
| chr2:19,349,658–19,351,441 | 2.4 kb | Proximal (<10kb) Multiome | 369 | |
| chr2:19,351,547–19,352,361 | 3.5 kb | Proximal (<10kb) | 155 | |
| chr2:19,353,395–19,353,782 | 5.4 kb | Proximal (<10kb) | 48 | |
| chr2:19,355,692–19,359,423 | 10.6 kb | Distal (>10kb) Multiome | 616 | |
| chr2:19,863,073–19,864,223 | 515.6 kb | Distal (>10kb) Multiome HiCAR | 720 | |
| chr2:19,868,540–19,869,572 | 520.9 kb | Distal (>10kb) Multiome HiCAR | 302 | |
| chr2:20,661,529–20,662,170 | 1313.7 kb | Distal (>10kb) Multiome HiCAR | 410 | |
| chr2:20,665,114–20,668,353 | 1319.0 kb | Distal (>10kb) Multiome HiCAR | 705 |
Genomic view of the LINC01376 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.