Transcription factors with Perturb-seq knockdown data for LINC01320. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01320 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01320, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:34,363,733–34,365,073 | 370.8 kb | Distal (>10kb) Multiome HiCAR | 133 | |
| chr2:34,365,656–34,366,607 | 368.9 kb | Distal (>10kb) Multiome HiCAR | 184 | |
| chr2:34,729,942–34,730,127 | 4.9 kb | Proximal (<10kb) | 27 | |
| chr2:34,731,164–34,731,549 | 3.5 kb | Proximal (<10kb) | 12 | |
| chr2:34,733,939–34,734,324 | 747 bp | At TSS | 7 | |
| chr2:34,734,626–34,735,331 | at TSS | At TSS | 90 | |
| chr2:34,738,767–34,739,184 | 3.7 kb | Proximal (<10kb) | 65 |
Genomic view of the LINC01320 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.