Transcription factors with Perturb-seq knockdown data for LINC01170. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01170 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01170, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:124,263,684–124,264,509 | 174.5 kb | Distal (>10kb) Multiome | 325 | |
| chr5:124,277,608–124,278,921 | 160.5 kb | Distal (>10kb) Multiome | 253 | |
| chr5:124,308,874–124,309,980 | 129.1 kb | Distal (>10kb) Multiome | 277 | |
| chr5:124,438,329–124,439,473 | at TSS | At TSS | 178 | |
| chr5:124,439,598–124,439,860 | 1.0 kb | Proximal (<10kb) | 11 | |
| chr5:124,580,889–124,582,318 | 142.7 kb | Distal (>10kb) Multiome | 537 | |
| chr5:124,628,764–124,630,157 | 190.8 kb | Distal (>10kb) Multiome HiCAR | 604 | |
| chr5:124,651,333–124,652,287 | 213.3 kb | Distal (>10kb) Multiome | 722 | |
| chr5:124,735,238–124,735,792 | 296.9 kb | Distal (>10kb) Multiome | 371 |
Genomic view of the LINC01170 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.