Transcription factors with Perturb-seq knockdown data for LINC01012. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01012 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01012, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:27,472,233–27,473,587 | 221.0 kb | Distal (>10kb) Multiome | 1052 | |
| chr6:27,478,759–27,479,180 | 215.2 kb | Distal (>10kb) Multiome | 642 | |
| chr6:27,479,324–27,480,016 | 214.4 kb | Distal (>10kb) Multiome | 750 | |
| chr6:27,495,395–27,496,098 | 198.3 kb | Distal (>10kb) Multiome | 724 | |
| chr6:27,502,683–27,503,927 | 190.3 kb | Distal (>10kb) Multiome | 699 | |
| chr6:27,505,539–27,506,022 | 188.2 kb | Distal (>10kb) Multiome | 646 | |
| chr6:27,518,890–27,519,632 | 174.8 kb | Distal (>10kb) Multiome | 717 | |
| chr6:27,545,031–27,546,022 | 148.4 kb | Distal (>10kb) Multiome | 662 | |
| chr6:27,547,469–27,547,915 | 146.4 kb | Distal (>10kb) Multiome | 440 | |
| chr6:27,552,906–27,553,807 | 140.6 kb | Distal (>10kb) Multiome | 694 | |
| chr6:27,592,359–27,593,376 | 101.2 kb | Distal (>10kb) Multiome | 844 | |
| chr6:27,602,046–27,602,794 | 91.6 kb | Distal (>10kb) Multiome | 469 | |
| chr6:27,605,356–27,606,138 | 88.3 kb | Distal (>10kb) Multiome | 562 | |
| chr6:27,630,675–27,631,795 | 62.9 kb | Distal (>10kb) Multiome | 827 | |
| chr6:27,650,587–27,651,063 | 43.2 kb | Distal (>10kb) Multiome | 541 | |
| chr6:27,668,541–27,669,069 | 25.4 kb | Distal (>10kb) Multiome | 577 | |
| chr6:27,671,980–27,673,036 | 21.6 kb | Distal (>10kb) Multiome | 845 | |
| chr6:27,684,282–27,684,819 | 9.4 kb | Proximal (<10kb) Multiome | 652 | |
| chr6:27,687,268–27,688,540 | 6.4 kb | Proximal (<10kb) Multiome | 972 | |
| chr6:27,693,569–27,694,503 | at TSS | At TSS | 653 | |
| chr6:27,752,061–27,752,956 | 58.3 kb | Distal (>10kb) Multiome | 499 | |
| chr6:27,753,073–27,753,588 | 59.3 kb | Distal (>10kb) Multiome | 758 | |
| chr6:27,762,370–27,762,921 | 68.6 kb | Distal (>10kb) Multiome | 65 | |
| chr6:27,772,302–27,773,105 | 78.6 kb | Distal (>10kb) Multiome | 784 | |
| chr6:27,791,232–27,791,741 | 97.4 kb | Distal (>10kb) Multiome | 564 | |
| chr6:27,791,916–27,792,609 | 98.3 kb | Distal (>10kb) Multiome | 728 | |
| chr6:27,806,645–27,808,975 | 114.0 kb | Distal (>10kb) Multiome | 963 | |
| chr6:27,809,816–27,810,576 | 116.1 kb | Distal (>10kb) Multiome | 914 | |
| chr6:27,813,688–27,816,146 | 120.9 kb | Distal (>10kb) Multiome | 564 | |
| chr6:27,836,792–27,839,128 | 144.4 kb | Distal (>10kb) Multiome | 1131 | |
| chr6:27,865,093–27,868,152 | 171.3 kb | Distal (>10kb) Multiome | 744 | |
| chr6:27,870,957–27,872,527 | 178.2 kb | Distal (>10kb) Multiome | 426 | |
| chr6:27,872,808–27,873,995 | 179.6 kb | Distal (>10kb) Multiome | 372 | |
| chr6:27,889,436–27,895,972 | 199.2 kb | Distal (>10kb) Multiome | 1215 | |
| chr6:27,902,800–27,903,766 | 209.0 kb | Distal (>10kb) Multiome | 891 |
Genomic view of the LINC01012 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.