Transcription factors with Perturb-seq knockdown data for LINC00276. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00276 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00276, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:14,400,783–14,401,373 | at TSS | At TSS | 30 | |
| chr2:14,401,530–14,402,684 | 1.1 kb | Proximal (<10kb) Multiome | 282 | |
| chr2:14,405,904–14,406,535 | 4.9 kb | Proximal (<10kb) | 34 | |
| chr2:14,631,920–14,635,950 | 231.7 kb | Distal (>10kb) Multiome | 655 |
Genomic view of the LINC00276 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.