Transcription factors with Perturb-seq knockdown data for LINC00205. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00205 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00205, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:45,073,773–45,075,747 | 213.6 kb | Distal (>10kb) Multiome | 883 | |
| chr21:45,286,648–45,288,846 | 52 bp | At TSS Multiome | 708 | |
| chr21:45,292,336–45,292,948 | 4.6 kb | Proximal (<10kb) Multiome | 599 | |
| chr21:45,403,955–45,406,352 | 117.0 kb | Distal (>10kb) Multiome | 551 | |
| chr21:45,555,336–45,556,476 | 268.0 kb | Distal (>10kb) Multiome | 868 |
Genomic view of the LINC00205 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.