The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for LIMS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIMS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIMS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:108,403,524–108,403,993 | 130.7 kb | Distal (>10kb) Multiome | 154 | |
| chr2:108,448,417–108,449,710 | 85.4 kb | Distal (>10kb) Multiome | 999 | |
| chr2:108,531,069–108,531,657 | 2.8 kb | Proximal (<10kb) | 48 | |
| chr2:108,533,404–108,535,229 | 202 bp | At TSS Multiome | 1035 | |
| chr2:108,583,732–108,584,281 | 49.6 kb | Distal (>10kb) Multiome | 283 | |
| chr2:108,608,990–108,609,565 | 74.9 kb | Distal (>10kb) Multiome | 125 | |
| chr2:108,620,806–108,621,587 | 86.7 kb | Distal (>10kb) Multiome | 401 | |
| chr2:108,636,177–108,636,884 | 102.1 kb | Distal (>10kb) Multiome | 398 | |
| chr2:108,718,922–108,720,037 | 185.0 kb | Distal (>10kb) Multiome | 1042 | |
| chr2:108,786,273–108,787,203 | 252.3 kb | Distal (>10kb) Multiome | 874 |
Genomic view of the LIMS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.