Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LIMD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIMD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIMD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:63,445,554–63,447,581 | 254.5 kb | Distal (>10kb) Multiome | 896 | |
| chr17:63,476,359–63,478,095 | 223.4 kb | Distal (>10kb) Multiome | 520 | |
| chr17:63,478,783–63,479,370 | 221.6 kb | Distal (>10kb) Multiome | 419 | |
| chr17:63,522,589–63,523,803 | 177.5 kb | Distal (>10kb) Multiome | 705 | |
| chr17:63,549,660–63,551,443 | 150.4 kb | Distal (>10kb) Multiome | 1037 | |
| chr17:63,600,715–63,601,423 | 99.8 kb | Distal (>10kb) Multiome | 1122 | |
| chr17:63,621,512–63,623,359 | 78.6 kb | Distal (>10kb) Multiome | 956 | |
| chr17:63,696,623–63,696,912 | 3.2 kb | Proximal (<10kb) | 195 | |
| chr17:63,698,705–63,701,428 | 536 bp | At TSS Multiome | 663 | |
| chr17:63,741,119–63,742,935 | 41.2 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:63,773,179–63,774,727 | 73.1 kb | Distal (>10kb) Multiome | 1169 | |
| chr17:63,826,794–63,828,024 | 126.7 kb | Distal (>10kb) Multiome | 1008 | |
| chr17:63,841,547–63,843,442 | 142.3 kb | Distal (>10kb) Multiome | 1203 | |
| chr17:63,848,836–63,849,566 | 148.5 kb | Distal (>10kb) Multiome | 658 | |
| chr17:63,960,119–63,962,604 | 261.2 kb | Distal (>10kb) Multiome | 445 | |
| chr17:63,998,051–63,998,826 | 297.7 kb | Distal (>10kb) Multiome | 408 |
Genomic view of the LIMD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.