Enables inorganic diphosphate phosphatase activity and protein homodimerization activity. Involved in phosphate-containing compound metabolic process. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LHPP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LHPP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LHPP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:124,388,665–124,389,857 | 72.5 kb | Distal (>10kb) Multiome | 506 | |
| chr10:124,417,910–124,419,729 | 42.8 kb | Distal (>10kb) Multiome | 794 | |
| chr10:124,448,804–124,450,505 | 11.7 kb | Distal (>10kb) Multiome | 289 | |
| chr10:124,454,050–124,454,394 | 7.4 kb | Proximal (<10kb) | 94 | |
| chr10:124,461,513–124,462,370 | 135 bp | At TSS Multiome | 629 | |
| chr10:124,469,789–124,470,407 | 8.3 kb | Proximal (<10kb) Multiome | 215 | |
| chr10:124,565,553–124,566,190 | 104.1 kb | Distal (>10kb) Multiome | 253 | |
| chr10:124,743,297–124,744,966 | 282.6 kb | Distal (>10kb) Multiome | 546 |
Genomic view of the LHPP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.