This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LHFPL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LHFPL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LHFPL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:78,359,821–78,361,240 | 288.6 kb | Distal (>10kb) Multiome | 965 | |
| chr5:78,499,278–78,500,053 | 149.2 kb | Distal (>10kb) Multiome | 122 | |
| chr5:78,631,764–78,632,823 | 16.7 kb | Distal (>10kb) Multiome | 145 | |
| chr5:78,647,879–78,649,652 | 120 bp | At TSS Multiome | 642 | |
| chr5:78,649,777–78,650,069 | 882 bp | At TSS | 106 | |
| chr5:78,689,782–78,690,552 | 41.3 kb | Distal (>10kb) Multiome | 97 | |
| chr5:78,771,124–78,771,783 | 122.5 kb | Distal (>10kb) Multiome HiCAR | 183 | |
| chr5:78,907,698–78,908,761 | 259.5 kb | Distal (>10kb) Multiome HiCAR | 489 | |
| chr5:78,927,570–78,928,199 | 278.9 kb | Distal (>10kb) Multiome HiCAR | 249 | |
| chr5:78,984,328–78,985,552 | 335.9 kb | Distal (>10kb) Multiome HiCAR | 723 |
Genomic view of the LHFPL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.