Predicted to be involved in inhibitory synapse assembly. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LGI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LGI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LGI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:24,795,107–24,795,850 | 235.4 kb | Distal (>10kb) Multiome | 178 | |
| chr4:24,799,487–24,800,855 | 230.9 kb | Distal (>10kb) Multiome | 178 | |
| chr4:24,912,021–24,913,398 | 118.2 kb | Distal (>10kb) Multiome | 420 | |
| chr4:24,988,783–24,989,362 | 42.0 kb | Distal (>10kb) Multiome | 120 | |
| chr4:25,030,155–25,031,590 | 39 bp | At TSS Multiome | 304 | |
| chr4:25,032,268–25,033,116 | 1.3 kb | Proximal (<10kb) | 57 | |
| chr4:25,159,654–25,161,108 | 129.5 kb | Distal (>10kb) Multiome | 899 | |
| chr4:25,233,604–25,234,892 | 203.1 kb | Distal (>10kb) Multiome | 812 | |
| chr4:25,312,481–25,313,179 | 281.8 kb | Distal (>10kb) Multiome | 951 |
Genomic view of the LGI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.