Enables identical protein binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and negative regulation of growth hormone receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LEPROTL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LEPROTL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LEPROTL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:29,874,798–29,875,362 | 220.3 kb | Distal (>10kb) Multiome | 162 | |
| chr8:29,990,565–29,991,896 | 104.4 kb | Distal (>10kb) Multiome | 363 | |
| chr8:30,005,068–30,006,568 | 89.9 kb | Distal (>10kb) Multiome | 99 | |
| chr8:30,011,371–30,011,980 | 83.6 kb | Distal (>10kb) Multiome | 36 | |
| chr8:30,033,186–30,034,812 | 60.9 kb | Distal (>10kb) Multiome | 337 | |
| chr8:30,034,989–30,035,701 | 59.8 kb | Distal (>10kb) Multiome | 47 | |
| chr8:30,082,008–30,083,590 | 12.2 kb | Distal (>10kb) Multiome | 1023 | |
| chr8:30,087,943–30,088,717 | 7.2 kb | Proximal (<10kb) Multiome | 89 | |
| chr8:30,094,567–30,095,766 | 41 bp | At TSS Multiome | 743 | |
| chr8:30,155,587–30,157,134 | 61.0 kb | Distal (>10kb) Multiome | 798 | |
| chr8:30,227,068–30,227,925 | 132.2 kb | Distal (>10kb) Multiome | 398 | |
| chr8:30,339,419–30,340,356 | 244.4 kb | Distal (>10kb) Multiome | 302 | |
| chr8:30,382,832–30,383,366 | 287.6 kb | Distal (>10kb) Multiome | 188 | |
| chr8:30,383,830–30,385,512 | 289.1 kb | Distal (>10kb) Multiome | 578 |
Genomic view of the LEPROTL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.