Enables R-SMAD binding activity. Involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LDLRAD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LDLRAD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LDLRAD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:12,946,945–12,948,745 | 269.7 kb | Distal (>10kb) Multiome | 1139 | |
| chr18:12,989,036–12,990,533 | 228.2 kb | Distal (>10kb) Multiome | 336 | |
| chr18:12,990,680–12,991,971 | 226.4 kb | Distal (>10kb) Multiome | 977 | |
| chr18:13,003,392–13,003,928 | 214.1 kb | Distal (>10kb) Multiome | 168 | |
| chr18:13,216,134–13,216,581 | 915 bp | At TSS | 275 | |
| chr18:13,216,871–13,219,231 | 178 bp | At TSS Multiome | 503 | |
| chr18:13,611,083–13,611,551 | 1.1 kb | Proximal (<10kb) | 162 | |
| chr18:13,611,713–13,612,773 | at TSS | At TSS | 250 |
Genomic view of the LDLRAD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.