Transcription factors with Perturb-seq knockdown data for LBX1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LBX1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LBX1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:101,223,495–101,223,894 | 5.7 kb | Proximal (<10kb) | 60 | |
| chr10:101,225,356–101,225,603 | 4.0 kb | Proximal (<10kb) | 72 | |
| chr10:101,227,006–101,227,506 | 2.1 kb | Proximal (<10kb) | 95 | |
| chr10:101,228,247–101,229,250 | 342 bp | At TSS | 189 | |
| chr10:101,229,411–101,229,811 | at TSS | At TSS | 179 | |
| chr10:101,229,930–101,230,494 | 337 bp | At TSS | 226 | |
| chr10:101,236,527–101,237,332 | 6.9 kb | Proximal (<10kb) | 123 | |
| chr10:101,238,847–101,239,018 | 9.3 kb | Proximal (<10kb) | 108 |
Genomic view of the LBX1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.