This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for LARS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:145,936,249–145,937,190 | 246.0 kb | Distal (>10kb) Multiome | 653 | |
| chr5:146,026,278–146,026,799 | 156.1 kb | Distal (>10kb) Multiome | 138 | |
| chr5:146,073,032–146,074,223 | 109.0 kb | Distal (>10kb) Multiome | 179 | |
| chr5:146,182,165–146,183,510 | 139 bp | At TSS Multiome | 994 | |
| chr5:146,202,953–146,204,079 | 20.9 kb | Distal (>10kb) Multiome | 825 | |
| chr5:146,338,076–146,339,360 | 156.2 kb | Distal (>10kb) Multiome | 195 | |
| chr5:146,344,641–146,346,403 | 162.3 kb | Distal (>10kb) Multiome | 236 | |
| chr5:146,446,778–146,447,873 | 264.6 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the LARS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.