This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for LANCL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LANCL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LANCL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:210,181,086–210,182,197 | 295.0 kb | Distal (>10kb) Multiome | 168 | |
| chr2:210,224,566–210,225,799 | 251.6 kb | Distal (>10kb) Multiome | 493 | |
| chr2:210,476,213–210,477,273 | 9 bp | At TSS Multiome | 848 | |
| chr2:210,477,506–210,477,816 | 801 bp | At TSS | 248 | |
| chr2:210,752,371–210,753,226 | 276.1 kb | Distal (>10kb) Multiome | 155 | |
| chr2:210,762,435–210,763,699 | 286.4 kb | Distal (>10kb) Multiome | 154 |
Genomic view of the LANCL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.