Enables RNA endonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LACTB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LACTB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LACTB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:70,401,617–70,404,779 | 265.1 kb | Distal (>10kb) Multiome | 1006 | |
| chr8:70,471,558–70,472,276 | 197.2 kb | Distal (>10kb) Multiome | 110 | |
| chr8:70,607,404–70,609,092 | 60.8 kb | Distal (>10kb) Multiome | 964 | |
| chr8:70,668,222–70,668,667 | 517 bp | At TSS | 405 | |
| chr8:70,668,771–70,669,616 | 3 bp | At TSS Multiome | 1018 | |
| chr8:70,804,960–70,805,938 | 136.3 kb | Distal (>10kb) Multiome | 161 |
Genomic view of the LACTB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.