This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for KYAT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KYAT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KYAT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:88,890,883–88,892,134 | 101.2 kb | Distal (>10kb) Multiome | 949 | |
| chr1:88,983,912–88,984,519 | 8.3 kb | Proximal (<10kb) | 149 | |
| chr1:88,991,587–88,991,863 | 912 bp | At TSS | 186 | |
| chr1:88,991,977–88,993,909 | 111 bp | At TSS Multiome | 925 | |
| chr1:88,997,721–88,997,905 | 4.9 kb | Proximal (<10kb) | 3 | |
| chr1:88,998,766–88,999,021 | 6.0 kb | Proximal (<10kb) | 113 | |
| chr1:89,523,795–89,525,737 | 532.1 kb | Distal (>10kb) Multiome HiCAR | 1043 |
Genomic view of the KYAT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.