Transcription factors with Perturb-seq knockdown data for KTN1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KTN1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KTN1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:55,411,377–55,412,204 | 168.3 kb | Distal (>10kb) Multiome | 795 | |
| chr14:55,579,635–55,581,317 | 2 bp | At TSS Multiome | 720 | |
| chr14:55,583,901–55,584,140 | 3.8 kb | Proximal (<10kb) | 104 | |
| chr14:55,730,593–55,731,050 | 150.7 kb | Distal (>10kb) Multiome | 138 | |
| chr14:55,748,902–55,749,661 | 169.2 kb | Distal (>10kb) Multiome | 180 | |
| chr14:55,864,862–55,865,309 | 285.0 kb | Distal (>10kb) Multiome | 147 |
Genomic view of the KTN1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.