Enables 14-3-3 protein binding activity and ATP binding activity. Involved in positive regulation of MAPK cascade. Located in cytosol; endoplasmic reticulum; and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KSR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KSR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KSR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:27,276,603–27,277,135 | 179.6 kb | Distal (>10kb) Multiome | 146 | |
| chr17:27,293,463–27,295,350 | 162.4 kb | Distal (>10kb) Multiome | 1050 | |
| chr17:27,332,329–27,333,408 | 123.4 kb | Distal (>10kb) Multiome | 951 | |
| chr17:27,339,666–27,340,740 | 116.2 kb | Distal (>10kb) Multiome | 417 | |
| chr17:27,345,040–27,345,796 | 111.0 kb | Distal (>10kb) Multiome | 236 | |
| chr17:27,348,891–27,350,020 | 107.2 kb | Distal (>10kb) Multiome | 369 | |
| chr17:27,353,475–27,354,485 | 102.5 kb | Distal (>10kb) Multiome | 870 | |
| chr17:27,455,680–27,457,139 | 178 bp | At TSS Multiome | 616 | |
| chr17:27,458,285–27,458,870 | 1.8 kb | Proximal (<10kb) | 354 | |
| chr17:27,461,638–27,461,829 | 5.2 kb | Proximal (<10kb) | 142 | |
| chr17:27,569,253–27,569,567 | 7.9 kb | Proximal (<10kb) | 306 | |
| chr17:27,574,040–27,574,398 | 3.1 kb | Proximal (<10kb) | 309 | |
| chr17:27,576,477–27,576,663 | 791 bp | At TSS | 110 | |
| chr17:27,576,804–27,577,025 | 429 bp | At TSS | 145 | |
| chr17:27,577,209–27,577,638 | at TSS | At TSS | 248 |
Genomic view of the KSR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.