The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KRT19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRT19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRT19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:40,615,478–40,615,916 | 912.6 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr17:40,637,853–40,638,362 | 890.2 kb | Distal (>10kb) Multiome HiCAR | 83 | |
| chr17:41,334,358–41,334,923 | 193.7 kb | Distal (>10kb) Multiome | 60 | |
| chr17:41,527,111–41,529,407 | 87 bp | At TSS Multiome | 635 | |
| chr17:41,529,883–41,531,145 | 2.2 kb | Proximal (<10kb) Multiome | 504 | |
| chr17:41,536,201–41,536,584 | 7.9 kb | Proximal (<10kb) | 200 | |
| chr17:41,548,740–41,549,518 | 20.8 kb | Distal (>10kb) Multiome | 698 | |
| chr17:41,579,549–41,580,064 | 51.4 kb | Distal (>10kb) Multiome | 335 | |
| chr17:41,647,765–41,648,495 | 119.7 kb | Distal (>10kb) Multiome | 519 | |
| chr17:41,662,549–41,663,015 | 134.5 kb | Distal (>10kb) Multiome HiCAR | 643 | |
| chr17:41,665,564–41,667,291 | 138.9 kb | Distal (>10kb) Multiome HiCAR | 883 | |
| chr17:41,688,103–41,690,064 | 160.5 kb | Distal (>10kb) Multiome | 1236 | |
| chr17:41,733,761–41,735,187 | 206.4 kb | Distal (>10kb) Multiome | 577 | |
| chr17:41,738,054–41,738,690 | 209.9 kb | Distal (>10kb) Multiome | 596 | |
| chr17:41,784,980–41,787,229 | 258.5 kb | Distal (>10kb) Multiome | 958 | |
| chr17:41,793,527–41,794,326 | 265.6 kb | Distal (>10kb) Multiome | 597 | |
| chr17:41,800,647–41,802,040 | 273.6 kb | Distal (>10kb) Multiome | 766 | |
| chr17:41,811,252–41,813,275 | 284.6 kb | Distal (>10kb) Multiome | 997 |
Genomic view of the KRT19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.