This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for KREMEN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KREMEN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KREMEN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:2,673,059–2,673,910 | 290.8 kb | Distal (>10kb) Multiome | 471 | |
| chr16:2,682,205–2,683,006 | 281.8 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:2,720,741–2,721,896 | 243.0 kb | Distal (>10kb) Multiome | 758 | |
| chr16:2,751,637–2,753,398 | 211.7 kb | Distal (>10kb) Multiome | 1074 | |
| chr16:2,776,766–2,778,256 | 186.9 kb | Distal (>10kb) Multiome | 828 | |
| chr16:2,867,958–2,868,665 | 95.9 kb | Distal (>10kb) Multiome | 960 | |
| chr16:2,882,042–2,883,813 | 81.3 kb | Distal (>10kb) Multiome | 838 | |
| chr16:2,904,002–2,906,321 | 60.0 kb | Distal (>10kb) Multiome | 994 | |
| chr16:2,911,480–2,912,624 | 52.4 kb | Distal (>10kb) Multiome | 784 | |
| chr16:2,954,158–2,954,471 | 9.8 kb | Proximal (<10kb) | 49 | |
| chr16:2,961,603–2,962,014 | 2.3 kb | Proximal (<10kb) | 334 | |
| chr16:2,963,159–2,965,475 | 312 bp | At TSS Multiome | 628 | |
| chr16:2,966,614–2,967,470 | 2.3 kb | Proximal (<10kb) | 99 | |
| chr16:2,968,641–2,970,561 | 4.9 kb | Proximal (<10kb) Multiome | 1039 | |
| chr16:2,979,651–2,981,140 | 16.2 kb | Distal (>10kb) Multiome | 795 | |
| chr16:2,981,390–2,982,257 | 17.5 kb | Distal (>10kb) Multiome | 460 | |
| chr16:3,003,612–3,004,589 | 39.8 kb | Distal (>10kb) Multiome | 652 | |
| chr16:3,007,583–3,008,956 | 44.2 kb | Distal (>10kb) Multiome | 514 | |
| chr16:3,009,722–3,010,376 | 45.8 kb | Distal (>10kb) Multiome | 395 | |
| chr16:3,017,242–3,018,799 | 53.9 kb | Distal (>10kb) Multiome | 451 | |
| chr16:3,019,969–3,022,268 | 56.0 kb | Distal (>10kb) Multiome | 963 | |
| chr16:3,022,890–3,024,532 | 59.9 kb | Distal (>10kb) Multiome | 933 | |
| chr16:3,027,854–3,029,038 | 64.1 kb | Distal (>10kb) Multiome | 546 | |
| chr16:3,036,222–3,037,148 | 72.6 kb | Distal (>10kb) Multiome | 256 | |
| chr16:3,045,413–3,047,408 | 81.9 kb | Distal (>10kb) Multiome | 510 | |
| chr16:3,058,226–3,060,102 | 95.1 kb | Distal (>10kb) Multiome | 769 | |
| chr16:3,098,550–3,100,475 | 136.0 kb | Distal (>10kb) Multiome | 454 | |
| chr16:3,106,146–3,106,906 | 142.4 kb | Distal (>10kb) Multiome | 851 | |
| chr16:3,123,818–3,124,940 | 160.1 kb | Distal (>10kb) Multiome | 800 | |
| chr16:3,134,425–3,135,445 | 170.7 kb | Distal (>10kb) Multiome | 752 | |
| chr16:3,149,357–3,151,137 | 186.4 kb | Distal (>10kb) Multiome | 975 | |
| chr16:3,152,009–3,153,129 | 188.5 kb | Distal (>10kb) Multiome | 889 | |
| chr16:3,156,990–3,157,742 | 193.1 kb | Distal (>10kb) Multiome | 680 | |
| chr16:3,158,260–3,159,345 | 194.6 kb | Distal (>10kb) Multiome | 764 | |
| chr16:3,171,474–3,172,591 | 207.9 kb | Distal (>10kb) Multiome | 574 | |
| chr16:3,174,125–3,174,566 | 210.0 kb | Distal (>10kb) Multiome | 371 | |
| chr16:3,175,429–3,175,953 | 211.4 kb | Distal (>10kb) Multiome | 483 | |
| chr16:3,182,514–3,183,488 | 218.6 kb | Distal (>10kb) Multiome | 690 | |
| chr16:3,187,874–3,189,822 | 225.2 kb | Distal (>10kb) Multiome | 679 | |
| chr16:3,191,282–3,192,194 | 227.5 kb | Distal (>10kb) Multiome | 509 | |
| chr16:3,234,780–3,235,610 | 271.0 kb | Distal (>10kb) Multiome | 845 | |
| chr16:3,263,988–3,264,941 | 300.3 kb | Distal (>10kb) Multiome | 923 |
Genomic view of the KREMEN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.