Transcription factors with Perturb-seq knockdown data for KPNB1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KPNB1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KPNB1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:47,423,404–47,423,999 | 225.7 kb | Distal (>10kb) Multiome | 129 | |
| chr17:47,531,659–47,532,268 | 117.2 kb | Distal (>10kb) Multiome | 159 | |
| chr17:47,648,863–47,650,987 | 212 bp | At TSS Multiome | 1152 | |
| chr17:47,693,705–47,695,210 | 45.0 kb | Distal (>10kb) Multiome | 619 | |
| chr17:47,733,002–47,733,810 | 83.8 kb | Distal (>10kb) Multiome | 366 | |
| chr17:47,789,633–47,790,336 | 140.6 kb | Distal (>10kb) Multiome | 395 | |
| chr17:47,831,256–47,831,955 | 182.1 kb | Distal (>10kb) Multiome | 856 | |
| chr17:47,840,790–47,841,702 | 191.8 kb | Distal (>10kb) Multiome | 833 | |
| chr17:47,847,253–47,848,429 | 198.3 kb | Distal (>10kb) Multiome | 193 | |
| chr17:47,850,617–47,851,614 | 201.7 kb | Distal (>10kb) Multiome | 694 | |
| chr17:47,895,361–47,896,955 | 246.7 kb | Distal (>10kb) Multiome | 1031 | |
| chr17:47,902,020–47,902,508 | 252.7 kb | Distal (>10kb) Multiome | 101 | |
| chr17:47,941,283–47,941,880 | 292.1 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the KPNB1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.