This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KNTC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KNTC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KNTC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:122,265,933–122,267,109 | 260.7 kb | Distal (>10kb) Multiome | 1060 | |
| chr12:122,421,844–122,422,754 | 104.8 kb | Distal (>10kb) Multiome | 685 | |
| chr12:122,500,206–122,501,493 | 26.3 kb | Distal (>10kb) Multiome | 955 | |
| chr12:122,526,435–122,527,753 | 198 bp | At TSS Multiome | 956 | |
| chr12:122,751,194–122,751,767 | 224.1 kb | Distal (>10kb) Multiome | 128 | |
| chr12:122,752,332–122,753,299 | 225.5 kb | Distal (>10kb) Multiome | 978 | |
| chr12:122,774,223–122,774,865 | 247.3 kb | Distal (>10kb) Multiome | 445 |
Genomic view of the KNTC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.