Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KLK10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLK10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLK10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:50,723,765–50,725,772 | 294.8 kb | Distal (>10kb) Multiome | 721 | |
| chr19:50,728,202–50,728,738 | 291.2 kb | Distal (>10kb) Multiome | 345 | |
| chr19:50,804,189–50,805,375 | 214.8 kb | Distal (>10kb) Multiome | 919 | |
| chr19:50,835,543–50,836,598 | 183.6 kb | Distal (>10kb) Multiome | 561 | |
| chr19:50,909,047–50,910,046 | 110.1 kb | Distal (>10kb) Multiome | 239 | |
| chr19:50,921,645–50,922,754 | 97.3 kb | Distal (>10kb) Multiome | 450 | |
| chr19:51,002,137–51,003,245 | 16.9 kb | Distal (>10kb) Multiome | 304 | |
| chr19:51,016,816–51,017,391 | 2.6 kb | Proximal (<10kb) Multiome | 394 | |
| chr19:51,018,853–51,019,319 | 1.5 kb | Proximal (<10kb) | 175 | |
| chr19:51,024,756–51,025,268 | 7.4 kb | Proximal (<10kb) | 86 | |
| chr19:51,064,766–51,065,479 | 45.4 kb | Distal (>10kb) Multiome | 227 | |
| chr19:51,107,794–51,109,056 | 88.7 kb | Distal (>10kb) Multiome | 750 | |
| chr19:51,311,132–51,312,279 | 291.9 kb | Distal (>10kb) Multiome | 99 |
Genomic view of the KLK10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.