Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in nucleoplasm. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLHL8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:86,934,199–86,936,649 | 285.7 kb | Distal (>10kb) Multiome | 1055 | |
| chr4:86,959,519–86,960,442 | 260.6 kb | Distal (>10kb) Multiome | 307 | |
| chr4:87,001,210–87,001,937 | 219.0 kb | Distal (>10kb) Multiome | 141 | |
| chr4:87,006,030–87,007,611 | 213.6 kb | Distal (>10kb) Multiome | 1004 | |
| chr4:87,030,741–87,031,834 | 189.3 kb | Distal (>10kb) Multiome | 395 | |
| chr4:87,219,648–87,221,398 | 51 bp | At TSS Multiome | 820 | |
| chr4:87,390,942–87,391,806 | 170.7 kb | Distal (>10kb) Multiome | 801 | |
| chr4:87,422,060–87,423,097 | 202.1 kb | Distal (>10kb) Multiome | 963 | |
| chr4:87,520,153–87,520,890 | 300.0 kb | Distal (>10kb) Multiome | 177 |
Genomic view of the KLHL8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.