KLHL23

kelch like family member 23 | FLJ37812, MGC22679, MGC2610

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-6 DE-6.18 Developmental clusters: GC4

Biological processes 6 terms

Cul3-RING ubiquitin ligase complex (GO:0031463)cytoplasm (GO:0005737)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)

Expression (TPM)

TFs regulating KLHL23 0 TFs

Transcription factors with Perturb-seq knockdown data for KLHL23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KLHL23

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:169,479,264–169,479,982	214.9 kb	Distal (>10kb) Multiome	907
chr2:169,573,179–169,574,073	120.6 kb	Distal (>10kb) Multiome	834
chr2:169,584,221–169,584,891	110.0 kb	Distal (>10kb) Multiome	994
chr2:169,694,097–169,694,854	11 bp	At TSS Multiome	898
chr2:169,733,252–169,734,532	39.4 kb	Distal (>10kb) Multiome	735
chr2:169,789,706–169,790,238	95.5 kb	Distal (>10kb) Multiome	539
chr2:169,798,658–169,799,453	104.4 kb	Distal (>10kb) Multiome	794
chr2:169,824,413–169,825,252	130.4 kb	Distal (>10kb) Multiome	946
chr2:169,827,076–169,828,199	133.0 kb	Distal (>10kb) Multiome	760

Genome Browser

Genomic view of the KLHL23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.